rolipram rol  (Tocris)

Journal: International Journal of Neuropsychopharmacology

Article Title: Inhibition of Phosphodiesterase 2 Ameliorates Post-Traumatic Stress–Induced Alcohol Intake Disorder by Regulating cAMP/cGMP Signaling

doi: 10.1093/ijnp/pyac064

Figure Lengend Snippet: The experimental schedule of single-prolonged stress (SPS) model to mimic post-traumatic stress disorder (PTSD)-like syndrome. Treatment schedule and test order for mice (A). The effects of Bay 60-7550 (Bay) on the latency to feed time (B) in the novelty suppressed feeding test (NSFT) and the percentages of open arm entries (C) and time spent in the open arms entries (D) in the elevated plus maze test (EPMT). Bay and rolipram (Rol) were injected (i.p.) through the whole experiment for 14 days. EIS, ethanol-induced sedation test; EM, ethanol metabolism test; LAT, locomotor activity test; QIT, quinine intake experiment; SAC, sacrifice; SIT, sucrose intake experiment; TBC, 2-bottle choice test. Values are the mean ± SEM. ** P < .01 vs. vehicle-treated control group; # P < .05, ## P < .01, and ### P < .001 vs. vehicle-treated SPS group.

Article Snippet: The selective PDE2 inhibitor Bay 60-7550 (Bay) and rolipram (Rol) were obtained from MedChem Express (USA) and Sigma Chemical Co. (USA).

Techniques: Injection, Activity Assay, Control

Journal: Journal of Clinical Medicine

Article Title: Rubus occidentalis and Ellagic Acid Affect the Contractility of Penile Corpus Cavernosum Smooth Muscle through the Nitric Oxide-Cyclic Guanosine Monophosphate and Cyclic Adenosine 3′,5′-Monophosphate Signaling Pathway

doi: 10.3390/jcm11102947

Figure Lengend Snippet: Interaction between ROE (3 mg/mL) and UDE ( A ) 0.1 µM) or ROL ( B ) 1 µM) in the context of relaxation of the PCCSM ( n = 4). ROE: Rubus occidentalis extract, UDE: udenafil, ROL: rolipram, PCCSM: penile corpus cavernosum smooth muscle, UDE + ROE: ROE treatment after pretreatment with UDE, ROE + UDE: UDE treatment after pretreatment with ROE, ROL + ROE: ROE treatment after pretreatment with ROL, ROE + ROL: ROL treatment after pretreatment with ROE. Values are presented as means ± standard deviations. * p < 0.05, ** p < 0.001 vs. treatment with UDE or ROL.

Article Snippet: L-phenylephrine (PE), Nω-nitro-L-arginine methyl ester hydrochloride (L-NAME), 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ), MDL 12330A hydrochloride (MDL 12330A), H-89 dihydrochloride hydrate (H-89), dimethyl sulfoxide, ellagic acid (EA), and rolipram (ROL) were purchased from Sigma-Aldrich (St. Louis, MO, USA).

Techniques:

Journal: Journal of Clinical Medicine

Article Title: Rubus occidentalis and Ellagic Acid Affect the Contractility of Penile Corpus Cavernosum Smooth Muscle through the Nitric Oxide-Cyclic Guanosine Monophosphate and Cyclic Adenosine 3′,5′-Monophosphate Signaling Pathway

doi: 10.3390/jcm11102947

Figure Lengend Snippet: Interaction between EA (10 mM) and UDE ( A ) 0.1 µM) or ROL ( B ) 1 µM) in the context of relaxation of the PCCSM ( n = 4). EA: ellagic acid, UDE: udenafil, ROL: rolipram, PCCSM: penile corpus cavernosum smooth muscle, UDE + EA: EA treatment after pretreatment with UDE, EA + UDE: UDE after pretreatment with EA, ROL + EA: EA treatment after pretreatment with ROL, EA + ROL: ROL treatment after pretreatment with EA. Values are presented as means ± standard deviations. * p < 0.01, ** p < 0.001 vs. treatment with UDE or ROL.

Article Snippet: L-phenylephrine (PE), Nω-nitro-L-arginine methyl ester hydrochloride (L-NAME), 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ), MDL 12330A hydrochloride (MDL 12330A), H-89 dihydrochloride hydrate (H-89), dimethyl sulfoxide, ellagic acid (EA), and rolipram (ROL) were purchased from Sigma-Aldrich (St. Louis, MO, USA).

Techniques: